Simultaneous delivery of several antimicrobial drugs from multi‐compartment glycerol‐silicone membranes

Combining drugs is an efficient tool in fighting bacterial infections. It has been proven to enable increased antimicrobial activity compared mono-drug therapies. Current commercial dressings for treatment of infected wounds provide delivery one drug only. Therefore, there obvious need develop a technology enabling incorporation and release two more actives. Ideally, such should prevent potential cross-reactions between the during long-term storage. Here, concept compartmentalization within distinct glycerol domains glycerol-silicone elastomer membranes presented. Multiple are encapsulated different types hampering any cross-reactions. The simultaneously released upon contact with aqueous media kinetics can be precisely adjusted by tuning various material parameters, as content membrane thickness. Ultimately, capabilities evaluated against variety bacteria agar diffusion assay. effective species, which confirms efficiency even at minimum moisture levels. platform enables virtually unlimited combinations from families (e.g., antimicrobial, anti-inflammatory, pain relief agents) facilitating new ways treating wound disorders.